# Integrated treatment utilizing both Chinese and Western medicine for refractory diabetic foot ulcers: a case report

**Authors:** Luyao Wang, Changting Sheng, Jiaxin Liu, Rong Chen, Rensong Yue, Maoyi Yang, Zhipeng Hu

PMC · DOI: 10.3389/fendo.2025.1704770 · Frontiers in Endocrinology · 2025-11-05

## TL;DR

A 57-year-old man with severe diabetic foot ulcers showed significant improvement using a combined Chinese and Western medicine treatment approach.

## Contribution

Demonstrates the effectiveness of integrative treatment for advanced diabetic foot ulcers.

## Key findings

- The ulcer showed near-complete closure after 144 days of integrative treatment.
- HbA1c levels improved from 13.5% to 7.0%, indicating better metabolic control.
- Functional recovery and full epithelialization were confirmed at follow-up.

## Abstract

Diabetic foot ulcer (DFU) is a severe complication of diabetes associated with a high risk of amputation and long-term disability. We report the case of a 57-year-old man with a Wagner grade IV DFU whose condition continued to deteriorate despite two toe amputations. An integrative treatment strategy combining traditional Chinese medicine (TCM) and western medicine was subsequently employed and proved effective. The TCM regimen included oral decoctions and topical herbal applications, while the western medical approach encompassed targeted therapies including glycemic control, anti-infective therapy, circulatory enhancement, anticoagulation, neurotrophic support, and nutritional management. Over a 144-day course, the ulcer demonstrated near-complete closure at discharge, with full epithelialization and functional recovery confirmed at follow-up. HbA1c decreased from 13.5% to 7.0%, indicating improved metabolic control. This case illustrates that an integrative management strategy can effectively control infection, promote tissue regeneration, and restore limb function in advanced DFU.

## Linked entities

- **Diseases:** diabetes (MONDO:0005015)

## Full-text entities

- **Diseases:** ulcer (MESH:D014456), diabetes (MESH:D003920), DFU (MESH:D017719), infection (MESH:D007239)

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12626841/full.md

## References

61 references — full list in the complete paper: https://tomesphere.com/paper/PMC12626841/full.md

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Source: https://tomesphere.com/paper/PMC12626841