# Characteristics of Pathogens of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Hospitalized Patients: A Retrospective Study From 2010 to 2020

## TL;DR

This study examines the types and drug resistance of pathogens in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease from 2010 to 2020.

## Contribution

The study provides updated insights into pathogen distribution and drug resistance patterns in AECOPD patients over a ten-year period.

## Key findings

- 77.9% of AECOPD patients had monoinfection, while 22.1% had multiple infections.
- Gram-negative bacteria were the most common pathogens, with high resistance to ceftriaxone observed in several species.

## Abstract

The aim of the study is to evaluate the distribution and drug resistance of infectious pathogens in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

This is a retrospective study of AECOPD patients who underwent pathogen evaluation and drug susceptibility tests.

A total of 199 hospitalized AECOPD patients were analyzed. Among them, 77.9% had monoinfection, and 22.1% had multiple infections. Two hundred and eighty-eight strains were isolated, with 61.1% gram-negative, 3.8% gram-positive, and 35.0% fungi, while 58 strains were colonized. Common bacteria included Haemophilus parainfluenzae, Acinetobacter baumannii, and Pseudomonas aeruginosa. Staphylococcus aureus and Enterococcus faecalis were the main gram-positive cocci, and Pseudohyphae were the main fungi. Fifty gram-negative strains showed drug resistance (19 colonized strains), with high resistance to ceftriaxone in A. baumannii, P. aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Methicillin-resistant S. aureus was resistant to penicillin but sensitive to other antibiotics.

The study highlights the distribution of pathogens and the prevalence of drug-resistant strains among AECOPD patients.