# Unveiling the roles of SPP1+ macrophage and IGFBP2+ fibroblast in lung adenosquamous carcinoma through single-cell analysis

**Authors:** Yao Lin, Yaxin Chen, Dandan Xiong, Jing Huang, Hongmo Liu, Yawen Qi, Jinfeng Chen, Jun Meng, Yueqi Li, Jingyuan Yang, Yi Bao, Wenxing Li, Li Yang, Sanqi An

PMC · DOI: 10.1016/j.gendis.2025.101779 · Genes & Diseases · 2025-07-24

## Full-text entities

- **Genes:** IGFBP2 (insulin like growth factor binding protein 2) [NCBI Gene 3485] {aka IBP2, IGF-BP53}, SPP1 (secreted phosphoprotein 1) [NCBI Gene 6696] {aka BNSP, BSPI, ETA-1, OPN}
- **Diseases:** adenosquamous carcinoma (MESH:D018196), lung (MESH:D008171)

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## References

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Source: https://tomesphere.com/paper/PMC12624626