# METTL3 promotes esophageal squamous cell carcinoma progression and reduces chemosensitivity to paclitaxel through the CASP9/BIRC3-dependent apoptosis pathway

**Authors:** Pengxiang Ji, Bo Wan, Minghui Gao, Shaohua Yin, Han Wu, Junjie Wang, Yuting Ma, Weihua Xu, Minghua Wang

PMC · DOI: 10.1016/j.gendis.2025.101693 · Genes & Diseases · 2025-05-27

## Full-text entities

- **Genes:** METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit) [NCBI Gene 56339] {aka IME4, M6A, MT-A70, Spo8, hMETTL3}, BIRC3 (baculoviral IAP repeat containing 3) [NCBI Gene 330] {aka AIP1, API2, CIAP2, HAIP1, HIAP1, IAP-1}, CASP9 (caspase 9) [NCBI Gene 842] {aka APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56}
- **Diseases:** esophageal squamous cell carcinoma (MESH:D000077277)
- **Chemicals:** paclitaxel (MESH:D017239)

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## References

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Source: https://tomesphere.com/paper/PMC12624589