# Investigating fucoidan blend supplementation and resistance training in humans: a parallel randomized controlled trial design

**Authors:** Stephen D. Cousins, Samantha T.C Kucewicz, Daniel W.T Wundersitz, Blake E.G. Collins, Matthew B. Cooke, Nicola McKeown, Hericka B. Figueiredo Galvao, Stephanie M. Resciniti, Phil M. Lyristakis, Brett A. Gordon, Chris van der Poel

PMC · DOI: 10.1038/s41598-025-24066-9 · Scientific Reports · 2025-11-17

## TL;DR

This study found that fucoidan supplementation during resistance training may improve muscle performance and body composition in humans.

## Contribution

The study is the first to investigate fucoidan supplementation in humans during resistance training, revealing its potential benefits on anaerobic performance and body composition.

## Key findings

- Fucoidan supplementation significantly increased peak power and relative peak power during a Wingate test.
- Fucoidan improved lean body mass and reduced body fat percentage during resistance training.
- Both fucoidan and placebo groups showed increased strength, but no significant difference was observed between them.

## Abstract

Fucoidan extracted from brown algae has been shown to improve aerobic capacity and increase muscle size and strength in mice. Whether these beneficial effects translate to humans is unknown. This study investigated the effect of a resistance training program in combination with fucoidan supplementation on measures of strength and performance in apparently healthy adults. In a double-blind placebo control fashion, 20 participants (9 male and 11 female) were randomised to supplement with fucoidan (N = 10, 1 g/day) or placebo (N = 10, 1 g/day) during six weeks of resistance training. Body composition, muscle strength, anaerobic performance, and blood measurements were compared pre- and post-resistance training. Strength measured by 1 repetition max back squat was significantly increased in both placebo and fucoidan supplemented groups (p < 0.001), with no significant effect of treatment observed (p = 0.48). Peak power and relative peak power produced during a Wingate test were significantly increased in the fucoidan supplemented group only (p < 0.05). There was a significant treatment effect on body composition (p < 0.05), with the fucoidan supplemented group demonstrating a significant increase in lean body mass and a decrease in body fat % (p < 0.05). In conclusion, fucoidan supplementation during resistance training may provide a viable strategy for enhancing muscle anaerobic performance as well as improving metabolism and body composition.

## Full-text entities

- **Chemicals:** Fucoidan (MESH:C007789)
- **Species:** Homo sapiens (human, species) [taxon 9606], Phaeophyceae (brown algae, class) [taxon 2870], Mus musculus (house mouse, species) [taxon 10090]

## Full text

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## Figures

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12624114/full.md

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Source: https://tomesphere.com/paper/PMC12624114