# Dynamic MR of Muscle Contraction During Electrical Muscle Stimulation: Potential Application to the Evaluation of Neuromuscular Diseases

## TL;DR

This study explores using dynamic MRI during muscle stimulation to detect muscle dysfunction in neuromuscular diseases.

## Contribution

The study introduces dynamic MRI during neuromuscular electrical stimulation as a novel functional biomarker for muscle diseases.

## Key findings

- Strain and strain buildup rates were reduced in patients' soleus muscles compared to healthy controls.
- Fat fraction and water T2 measurements showed no significant differences between patients and controls.
- Dynamic MRI during stimulation detects functional impairments not visible in structural imaging.

## Abstract

Thanks to the rapid evolution of therapeutic strategies for muscular and neuromuscular diseases, the identification of quantitative biomarkers for disease identification and monitoring has become crucial. Magnetic resonance imaging (MRI) has been playing an important role by noninvasively assessing structural and functional muscular changes. This exploratory study investigated the potential of dynamic MRI during neuromuscular electrical stimulation (NMES) to detect differences between healthy controls (HCs) and patients with metabolic and myotonic myopathies. The study included 14 HCs and 10 patients with confirmed muscular diseases. All individuals were scanned with 3 T MRI with a protocol that included a multi‐echo gradient echo sequence for fat fraction quantification, multi‐echo spin‐echo for water T2 relaxation time calculation, and 3D phase contrast sequences during NMES. The strain tensor, buildup, and release rates were calculated from velocity datasets. Results showed that strain and strain buildup rate were reduced in the soleus muscle of patients compared to HCs, suggesting these parameters could serve as biomarkers of muscle dysfunction. Notably, there were no significant differences in fat fraction or water T2 measurements between patients and HCs, indicating that the observed changes reflect alterations in muscle contractile properties that are not reflected by structural changes. The findings provide preliminary evidence that dynamic muscle MRI during NMES can detect abnormalities in muscle contraction in patients with myotonia and metabolic myopathies, warranting further research with larger, more homogeneous patient cohorts.

This exploratory study investigated dynamic MRI during neuromuscular electrical stimulation (NMES) as a biomarker for muscular diseases. Fourteen healthy controls and ten patients with metabolic and myotonic myopathies underwent 3T MRI scanning. Results showed reduced strain and strain buildup rates in patients' soleus muscles compared to controls, while fat fraction and water T2 measurements showed no significant differences. These findings suggest dynamic MRI with NMES can detect functional impairment not captured by structural imaging, offering potential for disease monitoring.