This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
Retraction: E. adenophorum Induces Cell Cycle and Apoptosis of Renal Cells through Mitochondrial Pathway and Caspase Activation in Saanen Goat

Abstract
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TopicsCell death mechanisms and regulation · Mitochondrial Function and Pathology · Natural Compounds in Disease Treatment
Following the publication of this article [1], concerns have been raised about Fig 2-6. Specifically:
In addition to the above concerns, the Institutional Animal Care and Use Committee approval number cited in this article (DKY-B20100805) has also been cited in multiple other articles that PLOS is aware of by different authors, published between 2012 and 2019 in [4–12], which report different research objectives in different species of animals.
The Fig 5C Cytoplasm Cyt c panel in [1] appears similar to content previously published in [2] (retracted in [3]) under a CC BY-NC 3.0 license. The reused content was modified. The Fig 5C Cytoplasm Cyt c panel in [1] is subject to the license that applies to the original article.
The authors did not respond to queries about these concerns. In the absence of underlying data, the above issues remain unresolved.
In light of the above unresolved concerns that question the reliability and integrity of these results, the PLOS One Editors retract this article [1].
All authors either did not respond directly or could not be reached.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1He Y, Chen W, Hu Y, Luo B, Wu L, Qiao Y, et al. E. adenophorum Induces Cell Cycle and Apoptosis of Renal Cells through Mitochondrial Pathway and Caspase Activation in Saanen Goat. P Lo S One. 2015;10(9):e 0138504. doi: 10.1371/journal.pone.0138504 26382060 PMC 4575129 · doi ↗ · pubmed ↗
- 2Zhou Z-W, Li X-X, He Z-X, Pan S-T, Yang Y, Zhang X, et al. Induction of apoptosis and autophagy via sirtuin 1- and PI 3K/Akt/m TOR-mediated pathways by plumbagin in human prostate cancer cells. Drug Des Devel Ther. 2015;9:1511–54. doi: 10.2147/DDDT.S 75976 25834399 PMC 4366042 · doi ↗ · pubmed ↗
- 3Induction of Apoptosis and Autophagy via sirtuin 1- and PI 3K/Akt/m TOR-Mediated Pathways by Plumbagin in Human Prostate Cancer Cells [Retraction]. Drug Des Devel Ther. 2022;16:2437–8. doi: 10.2147/DDDT.S 383775 35937567 PMC 9346404 · doi ↗ · pubmed ↗
- 4Ren Z, Yao R, Liu Q, Deng Y, Shen L, Deng H, et al. Effects of antibacterial peptides on rumen fermentation function and rumen microorganisms in goats. P Lo S One. 2019;14(8):e 0221815. doi: 10.1371/journal.pone.0221815 31469857 PMC 6716671 · doi ↗ · pubmed ↗
- 5Wan L, Ma J, Wang N, Wang D, Xu G. Molecular cloning and characterization of different expression of MYOZ 2 and MYOZ 3 in Tianfu goat. P Lo S One. 2013;8(12):e 82550. doi: 10.1371/journal.pone.0082550 24367523 PMC 3867352 · doi ↗ · pubmed ↗
- 6Jin L, Zhang M, Ma J, Zhang J, Zhou C, Liu Y, et al. Mitochondrial DNA evidence indicates the local origin of domestic pigs in the upstream region of the Yangtze River. P Lo S One. 2012;7(12):e 51649. doi: 10.1371/journal.pone.0051649 23272130 PMC 3521662 · doi ↗ · pubmed ↗
- 7Gu Y, Li M, Wang T, Liang Y, Zhong Z, Wang X, et al. Lactation-related micro RNA expression profiles of porcine breast milk exosomes. P Lo S One. 2012;7(8):e 43691. doi: 10.1371/journal.pone.0043691 22937080 PMC 3427246 · doi ↗ · pubmed ↗
- 8Chen B, Li D, Li M, Li S, Peng K, Shi X, et al. Induction of mitochondria-mediated apoptosis and PI 3K/Akt/ m TOR-mediated autophagy by aflatoxin B 2 in hepatocytes of broilers. Oncotarget. 2016;7(51):84989–98. doi: 10.18632/oncotarget.13356 27863407 PMC 5356714 · doi ↗ · pubmed ↗
