# Severe Bleeding From Portal Hypertension in a Young Patient With Common Variable Immunodeficiency-Associated Nodular Regenerative Hyperplasia

## TL;DR

A young patient with a rare immune disorder experienced severe bleeding due to liver complications linked to the condition.

## Contribution

This case report highlights a rare complication of CVID-related liver disease leading to severe bleeding.

## Key findings

- A young male with CVID developed noncirrhotic portal hypertension.
- The patient experienced recurrent parastomal bleeding due to liver complications.
- Nodular regenerative hyperplasia was identified as the underlying cause.

## Abstract

Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder causing hypogammaglobulinemia. Although rare, nodular regenerative hyperplasia is the most common liver complication in CVID, which can progress to noncirrhotic portal hypertension. We report a case of a young male with CVID presenting with recurrent parastomal bleeding secondary to noncirrhotic portal hypertension from CVID-associated nodular regenerative hyperplasia.