# Corticosterone Contributes to Context‐Triggered Retrieval of Morphine Withdrawal Memories by Acting on Basolateral Amygdala Neurons Projecting to Nucleus Accumbens Core

## TL;DR

This study shows how corticosterone, a stress hormone, helps trigger memories of morphine withdrawal by acting on specific brain cells, which could explain why people relapse.

## Contribution

The study identifies the role of mineralocorticoid receptors in BLA→NAcC neurons during context-triggered morphine withdrawal memory retrieval.

## Key findings

- Corticosterone contributes to context-triggered retrieval of morphine withdrawal memories.
- Mineralocorticoid receptors in BLA→NAcC neurons mediate this process.
- MR increases glutamate release and neuronal excitability during memory retrieval.

## Abstract

Context‐triggered retrieval of drug withdrawal memories (CTR‐DWM) is a major cause of drug relapse. Most studies of the context‐triggered retrieval of morphine withdrawal memories (CTR‐MWM) have mainly focused on the functional interactions within the central structures of the brain. It remains unknown how an increase in corticosterone, which is an important response under drug withdrawal state, participates in CTR‐MWM. The present results show that corticosterone contributes to CTR‐MWM; within the basolateral amygdala (BLA), it is the mineralocorticoid receptor (MR), rather than the glucocorticoid receptor (GR), activated by corticosterone that mediates CTR‐MWM; MR of BLA neurons projecting to the nucleus accumbens core (BLA→NAcC) mediates CTR‐MWM; MR increases presynaptic glutamate release and participates in dopamine D1 receptor ‐induced increase in presynaptic glutamate release and postsynaptic AMPA (α‐Amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic Acid) currents; MR increases intrinsic excitability of BLA→NAcC neurons during CTR‐MWM. These results suggest that corticosterone contributes to CTR‐MWM by activating BLA→NAcC neurons through MR pathways, uncovering a link between a systemic hormonal response and a specific CTR‐MWM process.

Context associated with morphine withdrawal elicits an increase in serum corticosterone levels. Corticosterone participates in CTR‐MWM by acting on MR, but not GR, in the BLA. MR in BLA→NAcC neurons mediates CTR‐MWM. MR increases presynaptic glutamate release and meanwhile participates in D1 receptor‐induced increases in presynaptic glutamate release and postsynaptic AMPA currents. MR increases the intrinsic excitability of BLA→NAcC neurons during CTR‐MWM.