# Low-Grade Myofibroblastic Sarcoma of the tongue: A case report and literature review

## TL;DR

This paper reports a rare case of low-grade myofibroblastic sarcoma in the tongue and reviews existing literature on the condition.

## Contribution

The novelty lies in presenting a new clinical case of LGMS in the tongue and emphasizing the need for long-term follow-up.

## Key findings

- LGMS in the tongue is extremely rare and presents as painless swelling.
- Histological and immunohistochemical features help distinguish LGMS from other sarcomas.
- Complete surgical excision with clear margins is the recommended treatment.

## Abstract

Low-grade myofibroblastic sarcoma (LGMS) is an extremely rare mesenchymal neoplasm. It arises from the differentiation of myofibroblasts and demonstrates a preference for the head and neck region. Herein, we present a case of LGMS in a 52-year-old man with painless swelling in the anterior right area of the tongue. Histologically, the lesion consisted of spindle-shaped cells exhibiting mild to moderate nuclear atypia, arranged in fascicles with a storiform pattern. Neoplastic cells were positive for SMA and negative for EMA, CD34, h-caldesmon, desmin, β-catenin, S100, SOX10, and NF, with a Ki-67 index of 15-20%. Complete surgical excision with clear margins was the treatment of choice. Very few cases of LGMS have been documented in the literature, and regular follow-up for these patients is essential for drawing reliable conclusions regarding local recurrence and the metastatic potential of this tumor.

Key words:Low-grade, myofibroblastic, sarcoma, tongue, myofibroblasts, immunohistochemistry.