# Management of oral lesions in toxic epidermal necrolysis with photobiomodulation: Report of three cases

## TL;DR

This paper reports three cases where photobiomodulation and antimicrobial photodynamic therapy improved oral lesions in patients with toxic epidermal necrolysis.

## Contribution

The study introduces a novel therapeutic approach combining PBMT and aPDT for managing oral lesions in TEN patients.

## Key findings

- PBMT and aPDT significantly improved oral lesions before skin manifestations improved.
- The treatment provided pain relief and accelerated tissue healing in all three patients.

## Abstract

Toxic epidermal necrolysis (TEN) is a mucocutaneous hypersensitivity reaction to certain drugs and/or infections that can lead to multisystem involvement. The oral cavity is affected in almost all cases. The aim of this study was to report three clinical cases of TEN managed with photobiomodulation therapy (PBMT) and antimicrobial photodynamic therapy (aPDT) for the treatment of oral lesions. All patients presented with oral ulcers at various locations. Treatment consisted of oral hygiene with 0.12% chlorhexidine digluconate combined with PBMT applied to strategic sites and aPDT applied to areas of secondary infection. The proposed therapeutic approach resulted in significant clinical improvement of the oral lesions, even prior to improvement of skin manifestations, including pain relief and accelerated tissue healing. These findings suggest that PBMT and aPDT may be effective in improving the oral condition of patients with TEN.

Key words:Toxic epidermal necrolysis, Photobiomodulation therapy, Antimicrobial photodynamic therapy.