# Multimodality treatment on gastric cancer with liver metastasis: case report

## TL;DR

A patient with advanced gastric cancer and liver metastases showed improved survival after a combination treatment including cryoablation and immunotherapy.

## Contribution

The paper presents a novel case of using cryoablation combined with immunotherapy for advanced gastric cancer with liver metastases.

## Key findings

- The patient achieved a partial response after cryoablation of liver metastases.
- Combining cryoablation with PD-1 inhibitors and chemotherapy led to 15 months of progression-free survival.
- Cryoablation may enhance anti-tumor immune responses when used with immunotherapy.

## Abstract

Advanced gastric cancer has a devastating prognosis, However, the optimal treatment for gastric cancer patients with multiple liver metastases(GCLM) remains yet to be fully elucidated. Cryoablation is a novel therapeutic approach that has the potential to induce tumor necrosis and elicit anti-tumor immune responses.

A 44-year-old male was diagnosed with advanced gastric adenocarcinoma. Despite undergoing multiple lines of systemic therapy and repeated locoregional treatments, the patient exhibited rapid tumor progression. Subsequent treatment with PD-1 inhibitors demonstrated limited efficacy. However, following the innovative application of cryoablation to eradicate a more significant lesion within the liver metastases, the patient achieved a partial response and experienced 15 months of progression-free survival (PFS) with the combined use of PD-1 inhibitors and chemotherapy at the time of this report.

Cryoablation combined with immunotherapy may provide potential benefits for specific patients and offer a meaningful therapeutic strategy for patients with advanced gastric cancer and liver metastases, which is worthy of further research.