# Impact of Abdominal Aortic Calcification on Long-Term Outcome after Gastric Cancer Surgery: a Retrospective Study

## TL;DR

This study found that higher abdominal aortic calcification is linked to worse survival and more cancer recurrence after gastric cancer surgery.

## Contribution

The study identifies abdominal aortic calcification as a novel predictor of gastric cancer prognosis and recurrence patterns.

## Key findings

- High abdominal aortic calcification is an independent risk factor for poor overall, disease-specific, and recurrence-free survival.
- Patients with higher calcification levels had significantly worse clinical outcomes after gastric cancer surgery.
- Abdominal aortic calcification is associated with increased peritoneal dissemination recurrence in gastric cancer.

## Abstract

This study examined the impact of abdominal aortic calcification, a known risk factor for cardiovascular disease, on the prognosis of patients undergoing radical surgery for gastric cancer.

The effects of abdominal aortic calcification on clinical outcomes, prognosis, and recurrence patterns were analyzed in 516 patients who underwent radical surgery for gastric cancer between 2010 and 2017.

After propensity score matching, patients with higher abdominal aortic calcification had significantly poorer overall survival (OS; P = 0.020), disease specific survival (DSS; P = 0.013), and recurrence-free survival (RFS; P = 0.017) than those with lower calcification levels. Multivariate Cox regression analysis identified a higher degree of abdominal aortic calcification as an independent risk factor for poor OS (hazard ratio, 2.57; 95% confidence interval, 1.56–4.22; P < 0.001), DSS (hazard ratio, 4.32; 95% confidence interval, 1.84–10.12; P < 0.001) and RFS (hazard ratio, 2.63; 95% confidence interval, 1.60–4.33; P < 0.001). High abdominal aortic calcification was also a risk factor for peritoneal dissemination recurrence in gastric cancer.

A high degree of abdominal aortic calcification was linked to poor prognosis and might increase peritoneal dissemination recurrence following curative resection for gastric cancer. Thus, abdominal aortic calcification may serve as a novel clinical tool for predicting the prognosis of patients with gastric cancer.

The online version contains supplementary material available at 10.1007/s12029-025-01339-0.