# A Septicemic Child due to a Novel Streptococcal Species, Streptococcus gwangjuensis

**Authors:** Benjawan Comhangpol, Sawita Srisawat, Naowarat Wangnadee, Kittiphong Matvises, Phatsaraporn Sirisa, Kotchaphan Sonoutha, Anusak Kerdsin

PMC · DOI: 10.1155/crdi/7886001 · 2025-11-07

## TL;DR

A child with a weakened immune system was diagnosed with septicemia caused by a new type of streptococcus bacteria and successfully treated with antibiotics and supportive care.

## Contribution

Identification of a novel streptococcal species, Streptococcus gwangjuensis, as a cause of septicemia in an immunocompromised child.

## Key findings

- Streptococcus gwangjuensis was identified as the causative agent of septicemia in an 8-year-old immunocompromised child.
- The isolate was susceptible to β-lactam antibiotics, aiding in effective treatment.
- Next-generation sequencing using sodA and gyrB amplicons confirmed the novel species.

## Abstract

We report a case of septicemia due to Streptococcus gwangjuensis in an immunocompromised 8-year-old child. The final diagnosis was febrile neutropenia associated with acute myeloid leukemia and septicemia. The patient was successfully treated with chemotherapy, granulocyte colony-stimulating factor, leukodepleted packed red cell transfusions, piperacillin/tazobactam, and meropenem. S. gwangjuensis was identified using sodA and gyrB amplicon-based next-generation sequencing. The isolate was susceptible to all β-lactam antibiotics.

## Linked entities

- **Chemicals:** piperacillin/tazobactam (PubChem CID 461573), meropenem (PubChem CID 441130)
- **Diseases:** acute myeloid leukemia (MONDO:0015667)
- **Species:** Streptococcus gwangjuensis (taxon 1433513)

## Full-text entities

- **Genes:** CSF3 (colony stimulating factor 3) [NCBI Gene 1440] {aka C17orf33, CSF3OS, GCSF}
- **Diseases:** febrile neutropenia (MESH:D064147), Septicemic (MESH:D010930), septicemia (MESH:D018805), acute myeloid leukemia (MESH:D015470)
- **Chemicals:** beta-lactam (MESH:D047090), piperacillin/tazobactam (MESH:D000077725), meropenem (MESH:D000077731)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12618117