Antioxidant and antidiabetic effects of Angylocalyx oligophyllus leaves aqueous extract in pregnant diabetic rats: Feto-maternal repercussions
Christian Tenezogang Takoukam, Marie Claire Tchamadeu, Sylvin Benjamin Ateba, William Yousseu Nana, Quelie Selakong Nzekuie, Armel-Kevin Pechi Fotso, Ahmadou Hassimatou, Calvin Bogning Zangue, Pascal Emmanuel Owona, Modeste Wankeu-Nya, Alain Bertrand Dongmo
TL;DR
This study shows that a plant extract from Angylocalyx oligophyllus can reduce diabetes-related complications in pregnant rats and improve fetal outcomes.
Contribution
The study demonstrates the antioxidant and antidiabetic effects of Angylocalyx oligophyllus extract in a preclinical model of diabetic pregnancy.
Findings
The extract reduced maternal hyperglycemia, lipid levels, and liver oxidative stress in diabetic pregnant rats.
It improved fetal outcomes by reducing malformations and increasing live births in diabetic rats.
The extract showed anti-α-amylase activity and normalized several maternal and fetal parameters.
Abstract
Pregestational diabetes mellitus can lead to many adverse outcomes during pregnancy both in the mother and her embryo/fetus. Plant-based products are empirically used as an alternative strategy to reduce these disorders. To investigate the effects of the Angylocalyx oligophyllus leaves aqueous extract on diabetes-induced metabolic, reproductive and fetal developmental disorders in pregnant diabetic rats, the in vitro anti-α-amylase and antioxidant plant effects first were evaluated. Then, adult virgin female rats primarily made diabetic by streptozotocin (35 mg/kg) and normal ones were mated with adult male rats. The pregnant rats were distributed into normal and diabetic control groups receiving distilled water, and diabetic rats groups treated with the plant extract doses (50, 100 and 200 mg/kg) or Glibenclamide (standard; 10 mg/kg). Animals were orally treated from 1st to 19th day of…
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Taxonomy
TopicsGestational Diabetes Research and Management · Natural Antidiabetic Agents Studies · Pregnancy and Medication Impact