Genome analysis of Actinobacillus pleuropneumoniae strain APPFJLYC01 reveals multidrug resistance and high virulence potential
Zhihong Fang, Zecheng Lin, Chuchu Duan, Xiaojin Liu, Zhongfeng Luo, Cuiqin Huang, Xiaohua Li, Xintian Zheng
TL;DR
A new strain of Actinobacillus pleuropneumoniae from China shows high virulence and multidrug resistance, posing a threat to the swine industry.
Contribution
The study provides a comprehensive genomic and pathogenic characterization of a novel multidrug-resistant and highly virulent A. pleuropneumoniae strain.
Findings
The APPFJLYC01 strain has 190 virulence factor homologs and 10 resistance genes.
It caused a 56% mortality rate in piglets during experimental infection.
The strain is closely related to another Chinese strain, JL03, based on phylogenetic analysis.
Abstract
Actinobacillus pleuropneumoniae is the primary etiological agent of porcine contagious pleuropneumonia, a devastating respiratory disease that causes substantial economic losses to the global swine industry. The emergence of multidrug-resistant strains with enhanced virulence poses increasing challenges to disease control and necessitates comprehensive genomic characterization to inform targeted intervention strategies. This study aimed to characterize the genomic features, antimicrobial resistance profile, and pathogenic potential of a novel A. pleuropneumoniae strain isolated from a severe outbreak in China, with particular focus on identifying unique resistance mechanisms and virulence determinants. We isolated strain APPFJLYC01 from lung and bronchial tissues of pigs during a severe pleuropneumonia outbreak in Fujian Province, China (incidence rate 30%, mortality rate 56%). Complete…
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Taxonomy
TopicsMicrobial infections and disease research · Bacillus and Francisella bacterial research · vaccines and immunoinformatics approaches