Regulation of hydrogen and oxidative stress in treating intestinal mucosa from ulcerative colitis

TL;DR

This study explores using hydrogen-releasing particles to treat ulcerative colitis by reducing oxidative stress and inflammation.

Contribution

A novel hydrogen storage particle (MgH2@MgO) is introduced for controlled hydrogen release to treat UC with minimal toxicity.

Findings

MgH2@MgO particles effectively scavenge ROS and reduce intestinal inflammation.

Hydrogen released from the particles inhibits the NF-κB signaling pathway.

The treatment reverses UC progression and shows potential for clinical use.

Abstract

Ulcerative colitis (UC) is a diffuse chronic inflammation in the superficial intestine. Excessive accumulation of reactive oxygen species (ROS) leads to the of the colorectal damage. As the anti-inflammation therapy needs to be last for at least 3–5 years, the drugs demand less toxicity. However, current treatments in the clinic are often accompanied by unavoidable adverse side effects. Hydrogen is a nontoxic antioxidant reagent with excellent permeability of biomembranes, which shows the potential in treating UC. A novel simply designed hydrogen storage particle, Magnesium Hydride (MgH2) particle with an outer shell of passivated Magnesium oxide (MgO), was constructed in the current study to enable the safe and controlled release of hydrogen. This studies demonstrated that magnesium hydride particle (MgH2@MgO) was effective in scavenging excessive ROS, relieving the inflammation, and reversing the progression of UC through inhibiting the NF-κB signaling pathway, which provided the experimental evidence for the clinical prevention and therapy of UC.

1. The suspension of hydrogen storage particles was given by retention enema. The hydrolysis reaction releases hydrogen gas into the intestinal cavity slowly and continuously; 2. The gas passes through cell membrane via passive diffusion; 3. The hydrogen neutralizes reactive oxygen species (ROS) and reduces mucosal damage caused by neutralizing oxidative stress in ulcerative colitis.Unlabelled Image

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