A novel brachytherapy and chemotherapy integrated ureteral stent: In vitro and in vivo study
Xiaotian Yang, Xueliang Zhou, Zhanyun Zhou, Yipu Li, Chengzhi Zhang, Yingqi Liu, Xiaohan Ma, Yanan Li, Yebin Wang, Dechao Jiao
TL;DR
A new ureteral stent combining brachytherapy and chemotherapy was tested in animals and showed promise in reducing tumor growth and safely functioning in the urinary tract.
Contribution
A novel integrated ureteral stent combining brachytherapy and chemotherapy was developed and tested for treating ureteral carcinoma.
Findings
The integrated stent significantly reduced T24 cell viability and inhibited migration and invasion in in vitro and in vivo studies.
The combination of brachytherapy and chemotherapy showed greater tumor suppression than either treatment alone in a xenograft mouse model.
The stent was successfully implanted in beagle dogs without surgical complications and induced tissue changes consistent with therapeutic effects.
Abstract
Ureteral carcinoma remains a major clinical challenge and requires effective localized treatment. Here, we report a novel 125I seed brachytherapy (ISB) and doxorubicin (DOX) chemotherapy integrated ureteral stent (IUS), which enables simultaneous urinary drainage and chemoradiotherapy. This study was divided into three parts. First, ISB and DOX significantly reduced T24 cell viability and inhibited migration and invasion in an in vivo study (p < 0.01). Second, a T24 xenograft mouse model demonstrated that the (DOX + ISB) group exhibited greater tumor suppression than the DOX (p = 0.08) and ISB (p = 0.02) groups, with decreased Ki‐67 and Bcl‐2 expression and increased apoptosis (all p < 0.01) in an in vitro study. Third, the IUS was successfully implanted in normal beagle dogs (n = 30) without surgical complications. The ureteral diameter increased with increasing cumulative…
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Taxonomy
TopicsUreteral procedures and complications · Kidney Stones and Urolithiasis Treatments · Urological Disorders and Treatments