# Indication-based electronic prescribing intervention reduces unnecessary meropenem use in a safety-net hospital: a quasi-experimental study

**Authors:** Jannet Manuela Reyna-Quito, Robert Glowacki, Huiyuan Zhang, William E. Trick, Vanessa Sardá

PMC · DOI: 10.1017/ash.2025.10148 · 2025-11-10

## TL;DR

An electronic alert system reduced unnecessary use of the antibiotic meropenem in a hospital without harming patients.

## Contribution

A targeted electronic prescribing alert effectively reduced meropenem use in a safety-net hospital.

## Key findings

- Meropenem use decreased by 41% after implementing the alert.
- Patient safety was not compromised by the intervention.

## Abstract

This quasi-experimental before-and-after intervention study evaluated an indication-based electronic prescribing alert in a 450-bed tertiary care hospital. Implementation reduced meropenem use by 41% without compromising patient safety, demonstrating the effectiveness of this targeted antimicrobial stewardship strategy.

## Linked entities

- **Chemicals:** meropenem (PubChem CID 441130)

## Full-text entities

- **Chemicals:** meropenem (MESH:D000077731)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12616565/full.md

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Source: https://tomesphere.com/paper/PMC12616565