# Temporal trends of inpatient oral penicillin challenges in a U.S. veteran cohort with a recorded penicillin allergy

## TL;DR

This study examines how often veterans with a penicillin allergy underwent oral penicillin challenges in U.S. hospitals, noting a significant increase in recent years.

## Contribution

The study highlights a recent rise in oral penicillin allergy challenges among veterans within the Veterans Health Administration.

## Key findings

- Almost half of the 616 inpatient oral penicillin challenges occurred in 2023 and 2024.
- The study identifies a growing trend in using oral challenges to evaluate penicillin allergy in veterans.

## Abstract

In a U.S. veteran cohort (2014 – 2024) with a listed penicillin allergy, we studied the characteristics of 616 veterans that underwent an inpatient oral penicillin challenge. Notably, almost half of these challenges occurred in 2023 and 2024, suggesting recent uptake of this penicillin allergy evaluation modality within the Veterans Health Administration.