Unveiling the Pharmacological Promise of Rondeletia leucophylla: A Multidimensional Approach
Najmus Sakib Minhaj, Rajib Das, Sadia Afreen Chowdhury, Monira Ahsan
TL;DR
This study explores the medicinal potential of Rondeletia leucophylla using multiple approaches, revealing its antioxidant, anti-inflammatory, and other therapeutic properties.
Contribution
The study provides a comprehensive phytochemical and pharmacological evaluation of Rondeletia leucophylla using in vitro, in vivo, and in silico methods.
Findings
The extract showed strong antioxidant activity with an IC50 of 28.87 μg/mL.
MERL exhibited significant antidiarrheal and anti-inflammatory effects comparable to standard drugs.
Molecular docking showed strong binding affinities to oxidative stress-related targets.
Abstract
Rondeletia leucophylla has traditionally been used to treat various ailments, though scientific evidence is limited. This study is aimed at exploring its phytochemical profile through in vitro, in vivo, and in silico investigations. The dried coarse powder of R. leucophylla stem and leaves was extracted with methanol, then concentrated and dried using a rotary evaporator. The extract was subsequently evaluated through in vitro and in vivo pharmacological assays, preliminary phytochemical screening with standard reagents, gas chromatography–mass spectrometry (GC‐MS) analysis, and various in silico approaches. Phytochemical screening of the methanolic extract of R. leucophylla (MERL) revealed the presence of steroids, carbohydrates, and glycosides, while GC‐MS identified 70 bioactive compounds. MERL showed a total phenolic content of 34.075 mg GAE/μg. Its DPPH assay indicated strong…
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Taxonomy
TopicsPhytochemistry and Biological Activities · Phytochemistry and Bioactive Compounds · Biological and pharmacological studies of plants