# The efficacy of ultrasound-guided radiofrequency ablation for the treatment of papillary thyroid carcinoma

## TL;DR

This study shows that ultrasound-guided radiofrequency ablation is more effective than surgery for treating papillary thyroid carcinoma, with better recovery and fewer complications.

## Contribution

The study provides new evidence comparing ultrasound-guided RFA and surgery for PTMC, highlighting RFA's clinical advantages.

## Key findings

- RFA was associated with better perioperative status, including shorter surgery time and less blood loss.
- RFA resulted in lower levels of thyroid hormones and inflammatory markers compared to surgery.
- RFA had a significantly lower complication rate than conventional surgical treatment.

## Abstract

This study compared the clinical value of ultrasound (US)-guided radiofrequency ablation (RFA) and conventional surgical treatment for papillary thyroid carcinoma (PTMC).

This retrospective cohort study included clinical data of PTMC patients who underwent routine surgical procedures or US-guided RFA treatment at Xinchang County People’s Hospital between April 2023 to July 2024. Perioperative status (surgical duration, intraoperative blood loss, length of hospital stay), changes in the levels of thyroid-related hormones and inflammatory factors and incidence of complications were compared.

A total of 125 patients met the criteria for this study. Among them, 60 patients underwent US-guided RFA (RFA group) and 65 underwent routine surgical procedures (surgical group). RFA was associated with better perioperative status than conventional surgery (P<0.05). After the surgery, the levels of thyroid-stimulating hormone (TSH) in both groups increased compared to preoperative levels and were significantly higher in the surgical group compared to the RFA group. The levels of free thyroxine (FT4) and free triiodothyronine (FT3) decreased compared to preoperative levels and were considerably lower in the surgical group than in the RFA group (P<0.05). Postoperative levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor - α (TNF - α) in both groups demonstrated a significant increase compared to preoperative level and were markedly higher in the surgical group compared to the RFA group (P<0.05). RFA was associated with a significantly lower incidence of complications compared to conventional surgery (5.00% vs 16.92%, respectively) (P<0.05).

US-guided RFA for treating PTMC is more effective than conventional surgical procedures and is associated with better perioperative status and levels of thyroid-related hormones, lower inflammatory response and lower incidence of complications.