Exploring the significance of GNG11, LPAR1, and AGTR1 in early diagnosis and prognosis of cervical cancer: A correlative analysis with clinical characteristics

TL;DR

This study explores how GNG11, LPAR1, and AGTR1 expression levels relate to cervical cancer diagnosis and prognosis, finding that GNG11 is particularly significant.

Contribution

The study identifies GNG11 as a potential diagnostic and prognostic biomarker for cervical cancer.

Findings

Low GNG11 expression correlates with larger tumor size, advanced FIGO stage, and lymph node metastasis.

High GNG11 expression is associated with longer overall and recurrence-free survival in cervical cancer patients.

GNG11 expression is an independent prognostic indicator for overall survival.

Abstract

To investigate the significance of G-protein gamma subunit 11 (GNG11) expression in the diagnosis and prognosis of cervical cancer (CC).

This was a retrospective study. Differentially expressed genes in CC were retrieved from the Gene Expression Omnibus (GEO). A cohort of 68 CC patients from General Hospital of Ningxia Medical University Cancer Hospital was enrolled in the study from March 2021 to March 2024. Immunohistochemistry was employed to evaluate the expression levels of G-protein subunit γ 11 (GNG11), lysophospholipid receptor 1 (LPAR1), and angiotensin II receptor 1 (AGTR1) in cancerous and pericancerous tissues of CC patients. The correlations between the positive expressions of GNG11, LPAR1, or AGTR1 and the clinicopathological parameters of CC patients were analyzed.

A significant correlation was observed between low positive expression of GNG11 and tumor size (P=0.0068), FIGO stage (P=0.0282), and lymph node metastasis (P=0.0101) in CC patients. Similarly, low positive expression of LPAR1 was correlated with FIGO stage (P=0.0024) and lymph node metastasis (P=0.0203). Patients exhibiting high positive expression of GNG11 demonstrated prolonged OS (P=0.0001) and RFS (P=0.0422) compared to those with low expression. Cox regression analysis revealed that FIGO stage (P=0.014), lymph node metastasis (P=0.002), and GNG11 expression (P=0.026) emerged as independent prognostic indicators for OS in CC patients.

The positive expression level of GNG11 is intricately linked to the early diagnosis and prognosis of CC, underscoring its potential as a significant diagnostic and prognostic indicator.

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