Transcriptomic comparison of avian auditory and vestibular sensory epithelia
Mitsuo Paul Sato, Ishwar Vithal Hosamani, Stefan Heller, Marie Kubota
TL;DR
This study compares gene activity in bird hearing and balance cells, revealing differences and similarities in their development and regeneration.
Contribution
The paper identifies unique gene expression patterns in avian auditory and vestibular hair cells and their regenerative states.
Findings
Auditory and vestibular hair cells in chickens have distinct transcriptomic profiles.
Regenerated auditory hair cells resemble utricle type II hair cells more than mature ones.
Regenerated hair cells lack type I utricle hair cell gene expression after damage.
Abstract
Our inner ears contain various hair cell subtypes with distinct cytomorphologies, innervation, and functions. Here, we computationally compared hair cell transcriptomes from the avian hearing organ, the basilar papilla, and the utricle, a vestibular organ, to explore how these subtypes differ in gene expression within a single species. We identified distinct gene expression patterns in auditory and vestibular hair cell subgroups. Next, we integrated existing transcriptomic datasets from regenerated nascent auditory hair cells and nascent utricle hair cells arising during natural turnover. We found that while nascent hair cells possess unique transcriptomic profiles, they are more similar to utricular type II hair cells than to their mature functional counterparts. Additionally, three weeks after aminoglycoside-induced hair cell loss in the utricle, the regenerated hair cells lacked type…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsMarine animal studies overview · Animal Vocal Communication and Behavior