# Editorial: Achilles heel of CAR T-cell therapy

**Authors:** Maurizio Chiriva-Internati, Fabio Grizzi

PMC · DOI: 10.3389/fimmu.2025.1724641 · 2025-10-31

## Full-text entities

- **Genes:** IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, HLA-A (major histocompatibility complex, class I, A) [NCBI Gene 3105] {aka HLAA}, CD19 (CD19 molecule) [NCBI Gene 930] {aka B4, CVID3}, FCER1G (Fc epsilon receptor Ig) [NCBI Gene 2207] {aka FCRG}, IL2 (interleukin 2) [NCBI Gene 3558] {aka IL-2, TCGF, lymphokine}, CD8A (CD8 subunit alpha) [NCBI Gene 925] {aka CD8, CD8alpha, IMD116, Leu2, p32}, CD28 (CD28 molecule) [NCBI Gene 940] {aka IMD123, Tp44}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, CD70 (CD70 molecule) [NCBI Gene 970] {aka CD27-L, CD27L, CD27LG, LPFS3, TNFSF7, TNLG8A}, CD247 (CD247 molecule) [NCBI Gene 919] {aka CD3-ZETA, CD3H, CD3Q, CD3Z, CD3ZETA, IMD25}, KLRK1 (killer cell lectin like receptor K1) [NCBI Gene 22914] {aka CD314, D12S2489E, KLR, NKG2-D, NKG2D}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, TRBV20OR9-2 (T cell receptor beta variable 20/OR9-2 (non-functional)) [NCBI Gene 6962] {aka CDR3, TCRBV20S2, TCRBV2O, TCRBV2S2O}, LAMP1 (lysosome associated membrane protein 1) [NCBI Gene 3916] {aka CD107a, LAMPA, LGP120}, CXADRP1 (CXADR pseudogene 1) [NCBI Gene 653108] {aka CAR, CXADRP}, HLA-C (major histocompatibility complex, class I, C) [NCBI Gene 3107] {aka D6S204, HLA-JY3, HLAC, HLC-C, MHC, PSORS1}, CAMK2G (calcium/calmodulin dependent protein kinase II gamma) [NCBI Gene 818] {aka CAMK, CAMK-II, CAMKG, MRD59}, IL1A (interleukin 1 alpha) [NCBI Gene 3552] {aka IL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1}, MSLN (mesothelin) [NCBI Gene 10232] {aka MPF, SMRP}
- **Diseases:** DLBCL (MESH:D016403), solid (MESH:D018250), B cell lymphoma (MESH:D016393), ovarian and metastatic renal cell carcinomas (MESH:D010051), acute lymphoblastic leukemia (MESH:D054198), cytotoxic (MESH:D064420), B cell acute lymphoblastic leukaemia (MESH:D015456), neuroblastomas (MESH:D009447), blood cancers (MESH:D019337), CRS (MESH:D003398), autoimmune diseases (MESH:D001327), Cancer (MESH:D009369), multiple myeloma (MESH:D009101), CLL (MESH:D015451)
- **Chemicals:** calcium (MESH:D002118), citrate (MESH:D019343), Cy (MESH:D003545), Bendamustine (MESH:D000069461), CART01 (-), Sodium citrate (MESH:D000077559), cyclophosphamide (MESH:D003520), fludarabine (MESH:C024352)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]
- **Cell lines:** CDX — Homo sapiens (Human), Prostate carcinoma, Cancer cell line (CVCL_UD76)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12615502/full.md

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Source: https://tomesphere.com/paper/PMC12615502