# Effectiveness of hybrid digital breast tomosynthesis/digital mammography in women presenting for routine screening at Maroondah BreastScreen, Australia: Interim analysis

## TL;DR

This study shows that a hybrid approach combining digital breast tomosynthesis and digital mammography is effective for breast cancer screening with faster reading times.

## Contribution

The study provides interim evidence on the feasibility and effectiveness of a hybrid DBT/DM screening approach in a large-scale trial.

## Key findings

- Hybrid DBT/DM had a cancer detection rate of 10.6 per 1,000 screens.
- Screen-reading time was approximately halved compared to standard DBT.
- Recall rate was 4.2% with a mean glandular dose of 2.49 mGy.

## Abstract

Hybrid digital breast tomosynthesis (DBT)/digital mammography (DM) (mediolateral oblique from DBT with synthetic 2D, craniocaudal from DM) can potentially improve breast cancer detection and address longer DBT screen-reading time. This pre-specified interim analysis presents the first 5,000 (of target 20,000) hybrid DBT/DM screens in an ongoing prospective trial in BreastScreen Australia. Cancer detection rate for hybrid DBT/DM was 10.6/1,000 screens; recall rate was 4.2 %; median screen-reading time was 36 seconds; and mean glandular dose was 2.49 mGy. Cancer detection and recall rates for hybrid DBT/DM were consistent with DBT metrics in a previous pilot study; screen-reading time was approximately halved.

•Hybrid DBT/DM screening showed comparable breast cancer detection and recall to previous estimates for two-view DBT.•Screen-reading time was approximately halved.•Interim results are encouraging for the potential feasibility of hybrid DBT/DM screening.

Hybrid DBT/DM screening showed comparable breast cancer detection and recall to previous estimates for two-view DBT.

Screen-reading time was approximately halved.

Interim results are encouraging for the potential feasibility of hybrid DBT/DM screening.