# Brachydactyly type A3 may be associated with shorter stature: An observation from a Chinese pediatric sample

## TL;DR

This study found that children with Brachydactyly type A3 in China are more likely to have shorter height and predicted adult height compared to those without the condition.

## Contribution

The study is the first to report an association between Brachydactyly type A3 and shorter stature in a large Chinese pediatric sample.

## Key findings

- Children with BDA3 had 0.30 SD lower average height and 0.22 SD lower predicted adult height compared to non-BDA3 children.
- The risk of shorter stature and shorter predicted adult height was 1.57 and 1.47 times higher in the BDA3 group, respectively.
- Children over 12 years with BDA3 had a significantly lower predicted adult height by about 2.0 cm compared to non-BDA3 children.

## Abstract

Brachydactyly type A3 (BDA3), a common finger deformity, demonstrates an inverse epidemiological relationship with population height, suggesting a potential link with individual stature. We aimed to investigate the distribution of BDA3 and its association with shorter stature in Chinese children.

From 2022 to 2023, we conducted a cross-sectional survey in 10 randomly selected schools in Beijing with children aged 3–18. We measured height on-site, obtained left hand-wrist X-rays, calculated predicted adult height (PAH) based on height and bone age, and diagnosed BDA3 deformity based on the X-ray images. And we compared the height and PAH between the BDA3 and Non-BDA3 groups by t-test or chi-square test, examined the association of BDA3 with shorter stature and shorter PAH using binary logistic regression model.

A total of 5,567 children participated, with 573 diagnosed with BDA3 (a detection rate of 10.3%). Notably, girls exhibited a significantly higher detection rate than boys (14.5% vs. 6.3%). The detection rate in children <6 years was twice that in those > 12 years(15.3% vs. 7.6%). The average height and PAH were 0.30 SD and 0.22 SD lower, and the risk of shorter stature and shorter PAH were 1.57 times and 1.47 times higher in the BDA3 group than in the Non-BDA3 group, respectively. And, children >12 years in the BDA3 group had a significantly lower PAH than those in the Non-BDA3 group (about 2.0 cm). Conclusion: Children with BDA3 are more likely to have shorter stature and shorter PAH than those with no BDA3 in Chinese children aged 3–18 years.