# Beyond the buzz: Grounding interoceptive interventions in mechanisms of brain–body coupling

**Authors:** Daniel S. Kluger, Teresa Berther, Martina Saltafossi, Jana Fehring, Joachim Gross

PMC · DOI: 10.1371/journal.pbio.3003439 · PLOS Biology · 2025-11-13

## TL;DR

This paper argues that understanding brain-body connections is essential for creating effective health interventions based on interoception.

## Contribution

The paper emphasizes the need for mechanistic insight and validation in interoception research for effective interventions.

## Key findings

- Mechanistic understanding of brain-body coupling is crucial for developing health interventions.
- Construct validity must be established before implementing body-based health strategies.

## Abstract

The field of interoception research is growing at a rapid pace. We need to establish mechanistic insight into brain–body interactions and validate readouts before we can develop effective body-based health interventions.

The field of interoception research is growing at a rapid pace. This Perspective highlights why establishing both mechanistic insight and construct validity will be critical prerequisites for developing effective body-based health interventions.

## Full-text entities

- **Diseases:** panic attack disorder (MESH:D016584), anxiety (MESH:D001007)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12614502/full.md

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Source: https://tomesphere.com/paper/PMC12614502