# Research progress of tsRNAs in kidney diseases

## TL;DR

This review explores how tsRNAs, small RNA fragments from tRNAs, are involved in kidney diseases and could serve as new diagnostic or therapeutic tools.

## Contribution

The paper provides a comprehensive review of tsRNAs' roles in kidney diseases and their potential as biomarkers and therapeutic targets.

## Key findings

- tsRNAs regulate gene expression, signal transduction, apoptosis, and inflammation in kidney diseases.
- tsRNAs are implicated in acute kidney injury, chronic kidney disease, and glomerulonephritis.
- tsRNAs show promise as biomarkers for diagnosis, prognosis, and treatment of renal disorders.

## Abstract

Transfer RNA-derived small RNAs (tsRNAs) are a class of regulatory non-coding RNAs generated through enzymatic cleavage of precursor or mature tRNAs. In recent years, tsRNAs have garnered growing interest in nephrology due to their diverse biological functions and potential clinical significance. This review summarizes current research on the roles of tsRNAs in kidney diseases, including their involvement in gene expression regulation, signal transduction, apoptosis, and inflammation-related pathways. We further highlight their emerging mechanistic contributions in conditions such as acute kidney injury, chronic kidney disease, and glomerulonephritis. Finally, we discuss the prospects of tsRNAs as novel biomarkers for early diagnosis, prognosis assessment, and therapeutic targeting in renal disorders, aiming to offer new insights into kidney disease pathogenesis and management.