# Draft genome sequence of Streptomyces sp. strain G6 reveals biosynthetic gene clusters, including lanthipeptides with potential biomedical applications

**Authors:** Michael Angelou L. Nada, Ursela G. Bigol

PMC · DOI: 10.1128/mra.00815-25 · Microbiology Resource Announcements · 2025-10-07

## TL;DR

The genome of Streptomyces sp. strain G6 contains gene clusters for making diverse natural products, including potential new antibiotics.

## Contribution

The discovery of novel biosynthetic gene clusters in a potentially new Streptomyces species.

## Key findings

- The genome encodes multiple biosynthetic gene clusters for natural product synthesis.
- Lanthipeptide gene clusters suggest potential biomedical applications.
- Genomic analysis indicates G6 may represent a novel Streptomyces species.

## Abstract

The 7.20 Mbp draft genome of Streptomyces sp. strain G6 encodes multiple biosynthetic gene clusters, including posttranslationally modified peptides, nonribosomal peptides, and polyketide synthases. Genomic analysis suggests that G6 is a novel species, highlighting its potential for novel antibiotic discovery.

## Full-text entities

- **Chemicals:** lanthipeptides (-)
- **Species:** Streptomyces sp. (species) [taxon 1931]

## Full text

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## Figures

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## References

24 references — full list in the complete paper: https://tomesphere.com/paper/PMC12613950/full.md

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Source: https://tomesphere.com/paper/PMC12613950