# Human papillomavirus partial L2 gene variants in the Barrett’s metaplasia-dysplasia-adenocarcinoma sequence

## TL;DR

This study examines HPV gene variants in the progression of Barrett’s esophagus to cancer, finding that HPV-16 is most common.

## Contribution

The study identifies the prevalence of HPV-16 over HPV-18 in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence.

## Key findings

- 32 out of 33 HPV partial L2 genes sequenced were HPV-16.
- Only one specimen was identified as HPV-18.
- Phylogenetic analysis highlights HPV-16's dominance in the disease progression.

## Abstract

High-risk human papillomavirus (HPV) genotypes 16 and 18 are associated with Barrett’s dysplasia and esophageal adenocarcinoma. We sequenced 33 HPV partial L2 genes from Australian esophageal specimens. Phylogenetic analysis showed 32 were HPV-16 and one was HPV-18, underscoring the predominance and importance of HPV-16.