# Evaluation of the effects of fucoidan extracted from sargassum angustifolium on coagulation factors and biochemical parameters in male Wistar rats

## TL;DR

This study examines how fucoidan from brown algae affects blood clotting and metabolism in rats, finding it lowers glucose and boosts iron levels without affecting clotting.

## Contribution

The study reveals fucoidan's hypoglycemic and iron-enhancing effects in vivo, with minimal impact on coagulation.

## Key findings

- Fucoidan did not significantly affect coagulation tests like Prothrombin Time and Thrombin Time.
- A dose-dependent reduction in glucose levels was observed in fucoidan-treated rats.
- Transferrin, iron, and ferritin levels increased significantly, suggesting improved iron absorption and storage.

## Abstract

This study investigates the effects of fucoidan extracted from Sargassum angustifolium on coagulation factors and biochemical parameters in male Wistar rats. Fucoidan, a sulfated polysaccharide from brown algae, is known for its anticoagulant, anti-cancer, and antioxidant properties

The study involved 25 rats, divided into control, sham, and three experimental groups, receiving varying doses of fucoidan (100, 150, and 200 mg/kg body weight) over 28 days. The research focused on Prothrombin Time, Thrombin Time, and Partial Thromboplastin Time, along with biochemical markers like glucose, total protein, iron-related parameters, and albumin

This study found that fucoidan administration did not significantly affect the hemostasis tests, suggesting minimal impact on coagulation pathways in vivo. However, a dose-dependent reduction in glucose levels was observed, highlighting the potential of fucoidan as a hypoglycemic agent. Additionally, significant increases in transferrin, iron, and ferritin levels were noted, implying enhanced iron absorption and storage

The findings underscore the therapeutic potential of fucoidan, particularly in managing glucose metabolism and iron homeostasis, while its minimal anticoagulant effect suggests safe usage in clinical settings where anticoagulation is undesirable. Further research is recommended to explore the full clinical benefits of fucoidan.