# Placental Vascular Resistance and Offspring Growth From Birth to Age 2 Years

## TL;DR

High placental vascular resistance during pregnancy is linked to increased risks of underweight and poor growth in children up to age 2.

## Contribution

This study reveals a novel association between early placental vascular resistance and long-term childhood growth impairment.

## Key findings

- Elevated placental vascular resistance at 21-24 weeks was linked to higher odds of childhood underweight and stunting.
- Increased vascular resistance across all gestational windows was associated with lower growth trajectories in early childhood.
- Monitoring Doppler indices during prenatal checkups may help identify children at risk for impaired growth.

## Abstract

What is the association of placental vascular resistance with children’s physical growth after birth?

This cohort study in 52 660 mother-infant pairs found that elevated placental vascular resistance was associated with higher risks of underweight and impaired growth during early childhood.

These findings suggest the importance of routinely monitoring Doppler indices during prenatal checkups while remaining vigilant regarding the risk of impaired growth in children with elevated placental vascular resistance.

This cohort study examines the association between placental vascular resistance and early-childhood physical growth among children in China.

Umbilical artery Doppler indices provide indirect measures of placental function, with elevated vascular resistance associated with adverse perinatal outcomes, but their association with postnatal growth remains understudied.

To examine the association between placental vascular resistance and early-childhood physical growth.

This cohort study used hospital electronic medical records and Maternal and Child Health Information System data of all singleton live births from May 18, 2012, to October 30, 2023, at Wuhan Children’s Hospital (Wuhan Maternal and Child Health Hospital).

Placental vascular resistance was assessed through routine prenatal Doppler ultrasonography measurements of pulsatility index, resistance index, and systolic-to-diastolic ratio across 4 gestational windows (21-24 weeks, 25-28 weeks, 29-32 weeks, and 33-36 weeks).

Child growth parameters from birth to age 2 years, including stunting, underweight, wasting, were defined as length for age, weight for age, and weight for length below the third percentile, respectively. Group-based multitrajectory modeling was conducted to characterize multiple trajectories of weight-for-age and length-for-age z scores.

A total of 52 660 mother-infant pairs were included (mean [SD] maternal age, 30.2 [3.9] years; 53.0% male offspring; mean [SD] gestational age, 38.8 [1.4] weeks). The prevalence rates of underweight, stunting, and wasting among children were 0.2% (n = 76), 0.3% (n = 101), and 0.8% (n = 284), respectively. Elevated placental vascular resistance at 21 to 24 weeks was associated with increased risks of childhood underweight (resistance index: odds ratio [OR], 1.27 [95% CI, 1.11-1.47]) and stunting (pulsatility index: OR, 1.29 [95% CI, 1.10-1.51]; resistance index: OR, 1.19 [95% CI, 1.05-1.35]; systolic-to-diastolic ratio: OR, 1.52 [95% CI, 1.11-2.07]). In the multitrajectory analysis, increased placental vascular resistance across all 4 gestational windows was significantly associated with a higher odds of children belonging to the persistently low, early-low and catch-up, and below-average groups and a lower odds of belonging to the persistently high group compared with the average group.

In this large cohort study of mother-child pairs followed up from pregnancy to childhood, elevated placental vascular resistance was associated with an increased risk of childhood underweight and stunting, highlighting the clinical importance of routinely monitoring Doppler indices during prenatal checkups.