# Structural and Functional Basis for Biased Agonism at the 5-hydroxytryptamine 5A Receptor

**Authors:** Xiaoyu Zhang, Linshan Xie, Peipei Chen, Jingjing Yu, Xiaowen Tian, Lei Wang, Jiali Wei, Zhenhua Shao, Wei Yan, Zheng Xu

PMC · DOI: 10.1186/s43556-025-00359-3 · Molecular Biomedicine · 2025-11-12

## Full-text entities

- **Genes:** OXER1 (oxoeicosanoid receptor 1) [NCBI Gene 165140] {aka GPCR, GPR170, TG1019}, GNAI1 (G protein subunit alpha i1) [NCBI Gene 2770] {aka Gi, HG1B, NEDHISB}, ARRB1 (arrestin beta 1) [NCBI Gene 408] {aka ARB1, ARR1}, GABBR1 (gamma-aminobutyric acid type B receptor subunit 1) [NCBI Gene 2550] {aka GABABR1, GABBR1-3, GB1, GPRC3A, NEDLC}
- **Diseases:** neuropsychiatric (MESH:C000631768), neuropsychiatric diseases (MESH:D004194)
- **Chemicals:** amide (MESH:D000577), 5-CT (MESH:C047087), 5-HT5AR (-), Gi (MESH:C001311), hydrogen (MESH:D006859), 5-HT (MESH:D012701)

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Source: https://tomesphere.com/paper/PMC12612430