# Glomerular disease associated with cancer: a case series of paraneoplastic nephrotic syndrome

## TL;DR

This paper reports cases of kidney disease linked to cancer, showing improvement with cancer treatment alone.

## Contribution

The study highlights rare cases of nephrotic syndrome linked to specific cancers and their response to oncological treatment.

## Key findings

- PNS was observed in patients with ovarian, pancreatic, and bladder cancers.
- Patients improved without corticosteroids or immunosuppressants.
- Cancer treatment was sufficient for remission in these cases.

## Abstract

The association between glomerular diseases and malignancies has been recognized since the 1920s. A diverse spectrum of glomerular lesions can occur in various neoplasms, including both hematologic malignancies and solid tumors. This study presents a case series of paraneoplastic nephrotic syndrome (PNS) associated with three solid tumors: ovarian cancer, pancreatic neuroendocrine tumor (NET), and bladder cancer. The occurrence of PNS is rarely reported in association with these malignancies. Notably, all patients achieved complete or partial remission without receiving corticosteroids or immunosuppressant therapy. These observations accentuate the critical role of malignancy in the pathogenesis of glomerulopathy and underscore the therapeutic primacy of oncological control in such patients.