# Global trends and inequalities in the burden of drug use disorders: a comprehensive analysis from 1990 to 2021 with future projections

## TL;DR

This study examines global trends in drug use disorders from 1990 to 2021, finding rising burdens and growing inequalities, especially linked to opioids.

## Contribution

The study provides a comprehensive global analysis of drug use disorders with future projections, highlighting opioid-related increases and inequality trends.

## Key findings

- DALYs from drug use disorders increased by 14.7% from 1990 to 2021.
- High-SDI countries and males aged 25–29 experienced the highest burden.
- Opioid use disorders are projected to drive a 12.9 million DALY increase by 2044.

## Abstract

Drug use disorders (DUDs) pose a major global health challenge, with limited comprehensive data across demographic and socioeconomic groups.

Using data from the Global Burden of Disease (GBD) 2021, we analyzed disability-adjusted life years (DALYs), deaths, prevalence, and incidence of DUDs from 1990 to 2021, stratified by sex, age, country, and Socio-Demographic Index (SDI). Trends were assessed using Joinpoint regression analysis, while cross-inequalities were evaluated through the Slope Index of Inequality (SII) and Concentration Index (CI). Nordpred projected future burden.

From 1990 to 2021, DALYs increased by 14.7%. Males and individuals aged 25–29 experienced the highest burden. High-SDI countries recorded the greatest DALYs and deaths. The SII increased from 82.4 in 1990 to 289.24 in 2021, and the CI revealed a disproportionate concentration of DUDs burden in high-SDI countries. Projections suggest that by 2044, DALYs will rise by 12.9 million, mainly due to opioid use disorders.

The global burden of DUDs has increased significantly with widening health inequalities across SDI levels. Targeted interventions, particularly addressing the opioid crisis, are essential to manage and mitigate future impacts.