# Paracentral acute middle maculopathy with cerebral infarction caused by carotid dissection: a case report

**Authors:** Huiqiong Tang, Lu Liu, Le Cao, Junfeng Liu, Bo Wu

PMC · DOI: 10.3389/fneur.2025.1698882 · Frontiers in Neurology · 2025-10-30

## TL;DR

A rare case links eye and brain issues caused by a carotid artery tear, highlighting the need for urgent evaluation.

## Contribution

This case report connects PAMM and cerebral infarction to carotid dissection without systemic risk factors.

## Key findings

- PAMM and cerebral infarction occurred due to carotid dissection in a patient without systemic risk factors.
- Visual and neurological symptoms improved after carotid stenting and antiplatelet therapy.
- OCTA confirmed retinal reperfusion following treatment.

## Abstract

Paracentral acute middle maculopathy (PAMM) is related to retinal capillary ischemia, occurring independently or secondary to systemic diseases. We report an unusual case of PAMM with cerebral infarction caused by carotid dissection without systemic risk factors.

A 55-year-old man presented with acute painless left visual loss and partial sensory aphasia, followed by right-sided weakness. Best-corrected visual acuity (BCVA) was 0.04 in the left eye. Optical coherence tomography (OCT) showed hyperreflective lesions at the OPL-INL junction; enface imaging revealed fern-like hyperreflective lesions in the inner nuclear layer (INL). OCT angiography (OCTA) demonstrated diffuse macular hypoperfusion. Brain MRI showed left basal ganglia infarction, and angiography confirmed left internal carotid artery (ICA) dissection and near occlusion. After carotid stenting and dual-antiplatelet therapy, BCVA improved to 0.8 at 3 months with OCTA-confirmed retinal reperfusion.

This is a report that links PAMM and cerebral infarction to carotid dissection, suggesting that PAMM should prompt urgent stroke and carotid workup in appropriate clinical context.

## Linked entities

- **Diseases:** cerebral infarction (MONDO:0002679)

## Full-text entities

- **Diseases:** retinal capillary ischemia (MESH:D012173), aphasia (MESH:D001037), carotid dissection (MESH:D020215), basal ganglia infarction (MESH:D007238), stroke (MESH:D020521), weakness (MESH:D018908), visual loss (MESH:D014786), PAMM (MESH:D000208), systemic diseases (MESH:D034721), cerebral infarction (MESH:D002544)

## Full text

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## Figures

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12611697/full.md

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Source: https://tomesphere.com/paper/PMC12611697