# Rates of parent‐reported allergic conditions in children at‐risk of celiac disease

## TL;DR

This study found that children at risk for celiac disease often have allergic conditions, but these allergies are not linked to developing celiac disease.

## Contribution

The study provides new insights into the prevalence of allergic conditions in children at risk for celiac disease and finds no association with celiac disease development.

## Key findings

- 19.8% of children at-risk for celiac disease had food protein-induced allergic proctocolitis.
- No significant association was found between allergic conditions and celiac disease development.
- The frequency of allergic conditions in this cohort was similar to that in healthy children.

## Abstract

Allergies and other chronic immune mediated conditions are becoming increasingly common. Here we utilized a prospective birth cohort called the Celiac Disease Genomic Environmental Microbiome and Metabolomic (CDGEMM) study to examine the frequency of parent reported allergic conditions and their association with celiac disease (CeD). We examined 271 children at‐risk of CeD from the United States and found a high frequency of allergic conditions. In our overall cohort, 19.8% reported food protein‐induced allergic proctocolitis (FPIAP), 12.5% reported IgE‐mediated food allergy, and 14.7% reported atopic dermatitis. Among the 23 children with CeD, 21.74% had FPIAP, 8.7% had an IgE‐mediated food allergy, and 21.74% had atopic dermatitis. No significant association between allergic conditions and CeD was found (p > 0.35 for all). These results highlight the widespread occurrence of parent‐reported allergic conditions in children but do not suggest an association between allergic conditions and CeD development.

The incidence and prevalence of allergic and other immune mediated diseases, such as celiac disease, are rising.Development of allergic conditions play a role in early immune system dysregulation.Allergic conditions can increase the likelihood of developing other allergic conditions over time.

The incidence and prevalence of allergic and other immune mediated diseases, such as celiac disease, are rising.

Development of allergic conditions play a role in early immune system dysregulation.

Allergic conditions can increase the likelihood of developing other allergic conditions over time.

We identified a high prevalence of parent‐reported allergic conditions in infants at‐risk for celiac disease.The frequency of food protein‐induced allergic proctocolitis was 19.8%, which is similar to previously described prevalence in a healthy cohort.We did not find an association between developing celiac disease and having an allergic condition in early childhood.

We identified a high prevalence of parent‐reported allergic conditions in infants at‐risk for celiac disease.

The frequency of food protein‐induced allergic proctocolitis was 19.8%, which is similar to previously described prevalence in a healthy cohort.

We did not find an association between developing celiac disease and having an allergic condition in early childhood.