# Symptoms of egg yolk‐associated food protein‐induced enterocolitis syndrome appear following prolonged cessation

## TL;DR

This study finds that egg yolk-related food allergy symptoms appear after a long break from eating egg yolk.

## Contribution

The study identifies a prolonged cessation period as a trigger for egg yolk-associated FPIES symptoms.

## Key findings

- Egg yolk consumption intervals during asymptomatic periods averaged 2.2 days.
- FPIES symptoms occurred after 17.1 days of egg yolk cessation.
- Prolonged cessation is linked to the onset of egg yolk-associated FPIES.

## Abstract

Food protein‐induced enterocolitis syndrome (FPIES) is a nonimmunoglobulin E (IgE)‐mediated food allergy. Most patients with solid FPIES experience a period of asymptomatic intake of the causative foods before onset. This study aimed to elucidate the pattern of egg yolk (EY) ingestion that triggers FPIES. We retrospectively compared consumption intervals during the asymptomatic period to those just before the first FPIES episode in 24 patients with oral food challenge test‐confirmed EY‐FPIES, for whom complete data regarding the dates of EY consumption before onset were available. The average interval during the asymptomatic period and that between the last asymptomatic consumption and onset were 2.2 ± 2.3 (median, 1; interquartile range [IQR], 1–3; 95% confidence interval [CI], 1.75–2.68) days and 17.1 ± 12.7 (median, 13; IQR, 8–29 days; 95% CI, 11.70–22.46), respectively. The onset of FPIES is associated with prolonged cessation after asymptomatic consumption.

Food protein‐induced enterocolitis syndrome (FPIES) is a nonimmunoglobulin E (IgE)‐mediated food allergy characterized by vomiting with or without constitutional symptoms, which occur 1–4 h after intake of the causative foods.Most patients with solid FPIES experience a period of asymptomatic intake of the causative foods before onset.

Food protein‐induced enterocolitis syndrome (FPIES) is a nonimmunoglobulin E (IgE)‐mediated food allergy characterized by vomiting with or without constitutional symptoms, which occur 1–4 h after intake of the causative foods.

Most patients with solid FPIES experience a period of asymptomatic intake of the causative foods before onset.

Average interval of egg yolk (EY) consumption was 2.2 ± 2.3 days during asymptomatic periods.First FPIES symptoms developed after 17.1 ± 12.7 days cessation of EY.Onset of FPIES is associated with prolonged cessation of the causative foods in patients with EY‐associated FPIES.

Average interval of egg yolk (EY) consumption was 2.2 ± 2.3 days during asymptomatic periods.

First FPIES symptoms developed after 17.1 ± 12.7 days cessation of EY.

Onset of FPIES is associated with prolonged cessation of the causative foods in patients with EY‐associated FPIES.