# Solid–Basaloid Adenoid Cystic Carcinoma of the Ipsilateral Breast Remnant in Postoperative Luminal HER2-Type Breast Cancer: A Case Report

**Authors:** Yuji Kobayashi, Kanako Miyazawa, Kayoko Shinseki, Akihiro Kushima, Masaya Takahashi, Mariko Fujibayashi

PMC · DOI: 10.70352/scrj.cr.25-0398 · Surgical Case Reports · 2025-11-06

## TL;DR

A rare case of solid–basaloid adenoid cystic carcinoma in the breast of a patient previously treated for breast cancer is reported.

## Contribution

This paper presents a rare case of SB-AdCC in a postoperative breast remnant, highlighting its aggressive nature and triple-negative classification.

## Key findings

- The patient had a high Ki-67 index of 80%, indicating high-grade malignancy.
- The tumor was diagnosed as triple-negative and SB-AdCC following histological examination.
- The patient showed no signs of metastasis one year after surgery and chemotherapy.

## Abstract

Solid–basaloid adenoid cystic carcinoma (SB-AdCC) is a rare and aggressive variant of AdCC of the breast. Moreover, it is an extremely rare subtype of triple-negative breast cancer, accounting for <1% of all breast cancers. We report a case of SB-AdCC.

Ten years ago, an 82-year-old woman underwent a partial mastectomy for the luminal HER2 (human epidermal growth factor receptor type 2)-type invasive ductal carcinoma of the left breast cancer. Ten years later, she noticed another lump in her left breast. A needle biopsy was performed, and an unclassified carcinoma was detected. Histological examination revealed that the carcinoma was of the triple-negative type. A mastectomy of the left breast and sentinel lymph node biopsy were performed. The postoperative pathological diagnosis was an SB-AdCC of the breast. The Ki-67 index was 80%, corresponding to a high-grade malignancy. She received postoperative chemotherapy with tegafur–gimeracil–oteracil potassium. At 1 year postoperatively, she is recovering well without signs of metastasis.

We reported a case of SB-AdCC.

## Linked entities

- **Proteins:** ERBB2 (erb-b2 receptor tyrosine kinase 2), Mki67 (antigen identified by monoclonal antibody Ki 67)
- **Chemicals:** tegafur–gimeracil–oteracil potassium (PubChem CID 54715158)
- **Diseases:** triple-negative breast cancer (MONDO:0005494), invasive ductal carcinoma (MONDO:0004953)

## Full-text entities

- **Genes:** ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19}
- **Diseases:** carcinoma (MESH:D009369), Breast Cancer (MESH:D001943), triple-negative breast cancer (MESH:D064726), AdCC of the breast (MESH:D061325), Adenoid Cystic Carcinoma (MESH:D003528), invasive ductal carcinoma of the left breast cancer (MESH:D018270), metastasis (MESH:D009362), Basaloid (MESH:C565284)
- **Chemicals:** tegafur (MESH:D005641), gimeracil-oteracil potassium (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12611522/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12611522/full.md

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Source: https://tomesphere.com/paper/PMC12611522