# Evaluating Compliance and Impact of the Sepsis Six Bundle in the Emergency Department: A Retrospective Cohort Study

## TL;DR

This study examines how well a sepsis treatment protocol called the Sepsis Six bundle is followed in emergency departments and its impact on patient outcomes.

## Contribution

The study provides real-world data on compliance with and outcomes of the Sepsis Six bundle in a tertiary care emergency department.

## Key findings

- Only 43.3% of patients presented with shock at admission.
- The majority of infections were lung-related, followed by brain, hematological, and kidney sources.
- A 32% mortality rate was observed among sepsis patients.

## Abstract

Background and objectives

Sepsis resuscitation bundles are the subject of numerous quality improvement initiatives that have recently been implemented globally. These educational initiatives have been shown to be associated with improvements in clinical outcomes. The aim of this study was to evaluate the compliance and impact of the Sepsis Six bundle in the emergency department (ED).

Methodology

A cohort study was conducted among 660 patients who had been diagnosed with sepsis in the ED of a tertiary care center.

Results

The mean age of study participants was 44.8±11.7 years. Of the total, 37% of the patients were female and 63% were male. Among the study participants, 286 (43.3%) patients had the presence of shock; 220 (33.3%) had the presence of sepsis at the time of admission, and 440 (66.7%) had the presence of sepsis after 24 hours of admission. The primary site of infection in the majority of study participants was the lung, followed by the brain, haematological origin, and the kidney. A mortality rate of 32% was noted.

Conclusion

Targeted quality improvement measures, staff training, and streamlined ED workflows are warranted to enhance adherence to the Sepsis Six bundle and ultimately improve survival rates in septic patients.