# Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice

## TL;DR

Stem cells in aged flatworms and mice can rejuvenate tissues, suggesting shared mechanisms that could improve human tissue repair in old age.

## Contribution

The study reveals conserved rejuvenating abilities of adult stem cells in aged flatworms and mice, offering insights for human regenerative medicine.

## Key findings

- Aged flatworm and mouse stem cells show rejuvenation after tissue regeneration.
- Regenerative abilities are limited in larger mammals' specific tissues.
- Findings suggest potential for enhancing human tissue plasticity in aging.

## Abstract

Adult resident stem cells are capable of regenerating tissues that manifest signs of “rejuvenation” in flatworms and mice of older ages. These findings suggest potentially conserved regulatory mechanisms of adult resident stem cells from worms to mammals. Regenerative capacities are more limited in specific tissues and stem cell types of larger mammals. Understanding and harnessing the rejuvenating properties of resident adult stem cells in flatworms and mice could have broad therapeutic implications for improving stem cell function and tissue plasticity across organ systems of humans in advanced age.

Resident stem cells from aged planaria and murine skeletal muscle possess some inherent abilities to mitigate signs of aging after tissue regeneration.