Decoding the Lipid Droplet Proteome: New Frontiers in Cardiovascular Disease Research

TL;DR

This paper reviews how studying proteins on lipid droplets can improve understanding and treatment of cardiovascular diseases.

Contribution

The paper provides a comprehensive overview of omics-based studies on lipid droplet proteomes in cardiovascular disease.

Findings

Lipid droplet proteins are linked to cardiovascular disease progression.

Omics technologies help identify potential diagnostic and therapeutic targets.

LD proteome analysis reveals roles in lipid metabolism and heart complications.

Abstract

Lipid droplets (LDs) are cellular dynamic organelles involved in lipid storage and maintaining lipid balance. They contain many proteins on their surface that significantly affect their functions and behaviors. Thus, it becomes crucial to characterize the LD proteome using appropriate “omics” technologies that may contribute to an accurate understanding of the LD roles in human diseases. Indeed, LDs and their associated proteins are involved in several pathologies related to dysfunctional lipid metabolism, such as hyperlipidemia, obesity, metabolic syndrome, and cardiovascular diseases (CVDs). This review aims to provide an overview of “omics” studies focused on characterizing the LD proteome in the cardiovascular field, offering additional insight into the involvement of LDs in the development and progression of heart complications, as well as defining potential targets useful for diagnostic, preventive, and therapeutic approaches for patients.

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