Eco-Friendly Synthesis of Silver Nanoparticles Using Lespedeza capitata Extract: Antioxidant and Anti-Inflammatory Properties in Zebrafish (Danio rerio)
Roxana Delia Chitiala, Ionut Iulian Lungu, Andreea-Maria Mitran, Ioana Mita-Baciu, Ion Brinza, Cornelia Mircea, Anisoara Nistor, Monica Hancianu, Radu Iliescu, Lucian Hritcu, Oana Cioanca
TL;DR
This study shows how to make eco-friendly silver nanoparticles using Lespedeza capitata extract and demonstrates their antioxidant and anti-inflammatory effects in zebrafish.
Contribution
A novel, eco-friendly method for synthesizing silver nanoparticles with demonstrated cognitive and behavioral benefits in zebrafish.
Findings
AgNPs synthesized using Lespedeza capitata extract showed a broad absorption band around 450 nm and a hydrodynamic diameter of 90.3 nm.
AgNPs improved memory and locomotor activity in scopolamine-induced zebrafish models.
STEM images confirmed spherical, well-dispersed nanoparticles with sizes between 15 and 20 nm.
Abstract
Silver nanoparticles (AgNPs) were synthesized using a modified literature method involving aqueous AgNO3 (3 mM) and plant extract (LCE) at a constant ratio, under alkaline conditions and controlled temperature. The nanoparticles were characterized by UV-Vis spectroscopy, dynamic light scattering (DLS), zeta potential analysis and scanning transmission electron microscopy (STEM). The UV-Vis spectra displayed a broad absorption band around 450 nm, indicative of polydispersity, while DLS revealed a hydrodynamic diameter of 90.3 nm with a polydispersity index of 0.3366. Zeta potential values suggested reduced electrostatic stability compared with previously reported plant-derived AgNPs, although STEM images confirmed predominantly spherical, well-dispersed nanoparticles with sizes between 15 and 20 nm. Functional assays in zebrafish demonstrated the biological relevance of AgNPs. In…
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Taxonomy
TopicsZebrafish Biomedical Research Applications · Nanoparticles: synthesis and applications · Advanced Nanomaterials in Catalysis