A Systematic Review and Meta-Analysis Investigating the Efficacy of Various Psychedelic Drugs for the Treatment of Substance Use Disorder
Eve E. Keighley, Eid Abo Hamza, Dalia A. Bedewy, Shahed Nalla, Ahmed A. Moustafa
TL;DR
This study reviews and analyzes the effectiveness of psychedelic drugs like ibogaine, LSD, and psilocybin in treating substance use disorder in humans.
Contribution
The study identifies ibogaine as the most effective psychedelic for reducing substance misuse behaviors and provides a meta-analysis of clinical trials.
Findings
Ibogaine showed the most prominent effect in treating substance use disorder.
Psychedelic treatment with or without psychotherapy showed similar effectiveness.
A total of 30 studies were included in the final meta-analysis.
Abstract
Objectives: This study investigates psychedelic drugs to treat substance use disorder (SUD). Researchers have recently begun conducting clinical trials of psychedelic treatment for SUD. The current meta-analysis investigates the extent of efficacy in alleviating SM behaviours (P) using psychedelic therapy (I), concurrent with determining which psychedelic enables the greatest effect (C) as a treatment tool for reducing SUD (O). Methods: The inclusion criteria in this study include evaluating the efficacy of LSD, psilocybin, ketamine, or ibogaine in human beings with an SUD. The exclusion criteria include studies on rodents, patients with schizophrenia, case studies, incomplete or ongoing trials, and studies with insufficient quantitative data. The search criteria obtained 1278 articles, acquired through PubMed and PsycINFO. After excluding literature, 30 papers were kept in the final…
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Taxonomy
TopicsPsychedelics and Drug Studies · Chemical synthesis and alkaloids · Forensic Toxicology and Drug Analysis