Arsenome, Arsenobolome, and Arsenobiolome
Fernando J. Pereira, Roberto López, A. Javier Aller
TL;DR
This paper explores how different forms of arsenic affect biology, focusing on their harmful and beneficial roles.
Contribution
It introduces the concepts of arsenome, arsenobolome, and arsenobiolome for comprehensive arsenic analysis.
Findings
Inorganic and organoarsenic species differ in metabolism and toxicity.
Arsenic compounds have potential in cancer treatment.
Efficient diagnosis and mitigation of arsenic intoxication are emphasized.
Abstract
A complete characterisation of the potential biological implications of any chemical species requires assessing as much information as possible about the dose of all physicochemical forms involved in its metabolic pathways or any other biological activity (beneficial or harmful). Research investigating the biological significance of arsenic species in living systems needs to involve not only the chemical characterisation of the complete set of arsenic-containing species (arsenome), but also the distinction of all arsenic-bearing metabolites (arsenobolome) and those arsenic-containing species involved directly in specific beneficial or harmful processes (arsenobiolome). This work offers insight into the above considerations regarding arsenic species that are of toxicological significance. We highlight the differences in the metabolic and toxicological behaviour of inorganic (iAs) and…
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Taxonomy
TopicsArsenic contamination and mitigation · Retinoids in leukemia and cellular processes · Selenium in Biological Systems