# Polyphenolic Compounds in the Prevention and Treatment of Hypertension: A Review

**Authors:** Remigiusz Olędzki

PMC · DOI: 10.3390/ijms262110665 · 2025-11-01

## TL;DR

This paper reviews how polyphenolic compounds from natural sources may help prevent and treat hypertension.

## Contribution

The paper provides a comprehensive review of polyphenolic compounds' therapeutic potential in hypertension prevention.

## Key findings

- Polyphenolic compounds show promise in reducing both primary and secondary hypertension.
- These compounds act through various mechanisms to counteract hypertension.
- Therapeutic and dietary recommendations are proposed based on current research.

## Abstract

In recent years, there has been a growing consumer interest in natural food raw materials and the bioactive compounds they contain. Current research findings from leading research centres on the effects of polyphenolic bioactive compounds have sparked a discussion on the use of polyphenolic compounds as natural therapeutics in the prevention of lifestyle diseases, including cardiovascular diseases such as hypertension. This paper reviews original scientific research on the potential use of polyphenolic bioactive compounds in reducing primary and secondary hypertension. The paper also describes the mechanisms by which bioactive compounds act in the process of counteracting hypertension. Based on these observations, key therapeutic and dietary recommendations for the prevention of hypertension are formulated.

## Full-text entities

- **Diseases:** cardiovascular diseases (MESH:D002318), Hypertension (MESH:D006973), lifestyle diseases (MESH:D004194)
- **Chemicals:** Polyphenolic Compounds (-)

## Figures

10 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12608774/full.md

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Source: https://tomesphere.com/paper/PMC12608774