# Effects of Acute Fish Oil Supplementation on Muscle Function and Soreness After Eccentric Contraction-Induced Muscle Damage

**Authors:** Sang-Rok Lee, Dean Directo, Yangmi Kang, Joshua Stein, Mason Calvert, Yong Woo An, Do-Houn Kim

PMC · DOI: 10.3390/nu17213408 · Nutrients · 2025-10-29

## TL;DR

This study found that a single dose of fish oil may help reduce muscle soreness and speed up recovery after intense exercise-induced muscle damage in young adults.

## Contribution

The study demonstrates the potential of acute fish oil supplementation to aid recovery from exercise-induced muscle damage in healthy individuals.

## Key findings

- Fish oil group recovered vertical jump and quadriceps torque to baseline by 48 hours, while the placebo group did not.
- Muscle soreness was significantly lower in the fish oil group at 48 hours post-exercise.
- Systemic TNF-α levels increased in both groups, but the placebo group showed a trend toward incomplete recovery.

## Abstract

Purpose: The primary aim of this study was to determine the efficacy of acute fish oil (FO) supplementation on indices of exercise-induced muscle damage (EIMD) in young healthy adults. Methods: Twenty-two healthy young male and females were randomly assigned to two experimental groups: fish oil (FO) or placebo control (CON). Participants performed a muscle damage protocol consisting of 10 sets of 10 plyometric drop jumps. Vertical jump height, isometric maximal voluntary contraction (MVC) torque, and systemic inflammation markers were assessed at pre-exercise, immediately post (post-0), post-24, post-48, and post-72 h. Results: Vertical jump performance and quadriceps peak torque significantly decreased in the CON group at post-0, 24, and 48 h (p < 0.05), while FO group recovered to baseline levels by post 48 h. Hamstring peak torque reductions recovered in the FO group at post-48 h but remained suppressed in the CON group until post-72 h (p < 0.05). Muscle soreness was significantly higher in the CON group compared to the FO group at post-48 h (p < 0.05). Systemic TNF-α levels significantly increased from baseline to post-0, 24, and 48 h in both groups (p < 0.05), with the CON group showing a trend toward incomplete recovery (p = 0.065). Conclusions: Our findings indicate that acute FO administration may modestly aid muscle recovery and reduce muscle soreness following EIMD in healthy young adults while the overall impact may be limited.

## Full-text entities

- **Genes:** TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}
- **Diseases:** inflammation (MESH:D007249), Muscle Damage (MESH:D009133), EIMD (MESH:D000092202), Muscle soreness (MESH:D063806)
- **Chemicals:** FO (MESH:D005395)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12608564/full.md

## References

44 references — full list in the complete paper: https://tomesphere.com/paper/PMC12608564/full.md

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Source: https://tomesphere.com/paper/PMC12608564