# Macrocyclic Aromatic Oligoamides with Diphenyladamantane Units: Conformational Change from Folded to Open by N-Alkyl Removal

## TL;DR

Scientists created macrocyclic molecules that change shape when certain chemical groups are removed, enabling the design of molecules with large inner spaces.

## Contribution

A new synthetic strategy was developed to control the conformation of macrocyclic aromatic oligoamides by modifying amide groups.

## Key findings

- Oligomers with tertiary amides adopt folded conformations due to cis-preference.
- Removing N-decyloxybenzyl groups leads to open conformations in secondary amide oligomers.
- The method allows creating macrocyclic molecules with large inner cavities.

## Abstract

Macrocyclic aromatic amide oligomers of various sizes containing tertiary amides and diphenyladamantane moieties were synthesized by condensation reactions using PhP3Cl2 or LiHMDS. The corresponding oligomers with secondary amides were obtained by removal of N-decyloxybenzyl groups from the amide nitrogen. X-ray crystal structure analysis showed that the oligomers with tertiary N-ethyl amides adopted folded conformations, consistent with the cis-preference of tertiary aromatic amides. In contrast, comparison of 1H NMR spectra and conformational analysis by force field calculations indicated that the oligomers with secondary amides adopted open conformations. These results also demonstrated that the synthetic strategy is effective for the preparation of macrocyclic molecules with large inner cavities.