# Shunt Surgery for Pediatric Prehepatic Portal Hypertension: A Single-Center Case Series

## TL;DR

This study examines the outcomes of shunt surgeries in children with prehepatic portal hypertension, showing improved long-term results and reduced complications.

## Contribution

The study provides real-world evidence supporting early surgical intervention for pediatric prehepatic portal hypertension.

## Key findings

- Five out of six surgically formed shunts functioned normally after an average of 4 years.
- All patients showed significant regression of esophageal varices six months post-surgery.
- Thrombocyte and leukocyte counts increased in five out of six patients during long-term follow-up.

## Abstract

Background/Objectives: Management of prehepatic portal hypertension involves endoscopic and medical therapies with subsequent shunting if symptoms persist. Lately, surgical shunts, particularly the Meso-Rex shunt, are increasingly considered early in the disease course, offering benefits such as minimized hyperammonemia, improved somatic growth, and preservation of liver function. Our study evaluates post-operative outcomes after different surgical procedures in children with prehepatic portal hypertension. Methods: This single-centre retrospective case series included six children undergoing surgical shunting for prehepatic portal hypertension over a 5-year period. Medical records before and after surgery, followed for an average of 4.0 years, were analyzed. Results: Five patients underwent a Meso-Rex bypass, while one patient underwent a mesorenal shunt procedure. All cases showed clinically significant regression of esophageal varices six months post-surgery. Thrombocyte as well as leukocyte count significantly increased in five out of six patients during the long-term follow-up. Currently, five out of six surgically formed shunts (83%) continue to function normally. Conclusions: Our study supports early surgical intervention for improved long-term outcomes in managing portal hypertension, reducing complications like hypersplenism and variceal bleeding. Early consideration and ongoing monitoring are crucial for long-term success in children with portal hypertension.